AutoClip· First indication: mitral TEER· 首个适应症:二尖瓣 TEER

Real-time AI reads the heart and guides repair. 实时 AI 读懂心脏,引导瓣膜修复。

During a catheter valve repair the operator steers by live ultrasound, and every decision is made by eye. AutoClip reads that image and gives the operator a measurement where there was a guess. 经导管瓣膜修复中,术者靠实时超声操作,每一个决策都凭肉眼。AutoClip 读懂这幅图像,在原来靠猜的地方给术者一个测量值。

Offline replay of a recorded procedure · not for clinical use真实手术录像离线回放 · 非临床使用
TCT 2025

Featured Innovation, San Francisco, while still a prototype旧金山 Featured Innovation,原型阶段即入选

~2,000

TEER procedures from four centres, under data-use authorizations例 TEER,来自四个中心,经数据使用授权

≈1.5 mm

clip-position error against expert labels, 34 held-out patients夹子位置与专家标注的误差,34 位留出验证患者

12 / 12

centres shown the demo asked to join external validation看过演示的中心全部要求参加外部验证

01The problem问题

Every TEER decision is still made by eye.TEER 的每一个决策,仍然靠肉眼。

Where to place the clip, when to grasp, whether to release. The operator reads a grey, moving image, and there is not a single number on the screen. The result decides the patient's outcome, and the result depends on who operates. 夹子放在哪、何时抓、能不能释放。术者读的是一幅灰色的动态图像,屏幕上没有一个数字。结果决定患者的结局,而结果取决于谁在做。

2–4mm

disagreement between four experienced specialists on the same frame and the same landmark: the papillary muscle that decides clip position.四位资深专家在同一帧、同一解剖标志上的分歧。这个标志是决定夹子位置的乳头肌。

Turicor inter-observer studyTuricor 观察者间一致性研究
38% vs 72%

death or heart-failure hospitalisation by two years, when residual leak after the procedure is minimal (≤1+) versus severe (≥3+).术后残余反流轻微(≤1+)与严重(≥3+)的患者,两年内死亡或心衰住院的比例。

COAPT · Kar et al., Circulation 2021
64% → 75%

optimal procedural success from an operator's first 25 cases to 50+. Most centres never reach fifty cases a year.术者前 25 例到 50 例以上的最佳手术成功率。多数中心一年做不到 50 例。

STS/ACC TVT Registry · Chhatriwalla et al., JACC 2019
02AutoClip

A number where there was a guess.原来靠猜的地方,现在有一个数字。

AutoClip segments 15 structures on every frame of the live echo (leaflet scallops, grippers, insertion points, papillary muscles, the clip) and turns them into a measurement for each of the three decisions. Decision support, not decision replacement: the operator stays in control. AutoClip 在实时超声的每一帧上分割 15 个结构(瓣叶分区、抓钳、插入点、乳头肌、夹子),把它们变成三个决策各自的测量值。辅助决策,不替代决策:控制权始终在术者手里。

Clip trajectory onto the valve in two echo planes, bicommissural and LVOT, with the angle to the target
01

Position定位

Is the clip on target?夹子对准目标了吗?

Today现在Estimated from two planes by eye.凭肉眼从两个切面估计。
AutoClipClip trajectory onto the target, in both planes.夹子在两个切面上相对目标的轨迹。
LVOT echo view of the clip with posterior and anterior leaflet insertion depth in millimetres
02

Grasp夹持

Are both leaflets inside?两侧瓣叶都夹进去了吗?

Today现在Judged on a moving image.在动态图像上判断。
AutoClipInsertion depth of each leaflet inside the clip, in millimetres.每侧瓣叶在夹子内的插入深度,以毫米计。
Colour Doppler after the clip next to the five-item release checklist, all criteria met
03

Release释放

Is the result good enough to let go?结果够好,可以释放了吗?

Today现在A judgement call, case by case.逐例凭经验判断。
AutoClipFive release criteria, each checked before letting go.五项释放标准,逐项核对后再释放。
03In the cath lab在导管室里

Nothing in the room has to change.导管室里什么都不用改。

In输入

Echo machine超声机

The video output it already has. Any vendor.它本来就有的视频输出。任何厂商。

AutoClip

A GPU box in the lab导管室里的一台 GPU 盒子

Reads every frame. No hospital network, no cloud.逐帧读图。不接医院网络,不上云。

Out输出

A second screen第二块屏幕

Measurements next to the live image the operator already watches.测量值显示在术者本来就在看的实时图像旁边。

Any clip任何夹子Device-agnostic. Built first for the clip with most of the market.不绑定器械。首先适配市场份额最大的夹子。
Any echo vendor任何超声厂商Works from the standard video signal, not a vendor interface.读取标准视频信号,不依赖厂商接口。
Today: offline replay现在:离线回放Running on recorded procedures now. Real-time on the live feed is the next build.目前在录像病例上运行。接实时视频流是下一步。
04Evidence证据

The model is only as good as the clinical definition.模型的上限,是临床定义的质量。

Our advantage is not generic computer vision. It is specialist knowledge turned into labels and protocols, trained on in-domain data, and tied to what happened to the patient.我们的优势不是通用计算机视觉,而是把专科知识变成标注和规程,用术中数据训练,并与患者的真实结局挂钩。

15

structures defined on every frame, by operators个结构,由术者定义,逐帧标注

235

patients annotated, ~10,000 frames, under a written protocol例患者已标注,约 10,000 帧,按书面规程

4

annotators cross-checked: the expert ceiling was measured before the model位标注者交叉核对:先测专家上限,再评模型

203

procedures linked to registry follow-up, to test which readouts predict outcome例手术关联登记库随访,检验哪些读数能预测结局

AutoClip segmentation results on the main screen at TCT 2025 in San Francisco, Mi Chen presenting at the podium
TCT 2025, San Francisco. Featured Innovation at the largest interventional cardiology meeting.全球最大介入心脏病学会议的 Featured Innovation。
Done已完成
  • 15-structure segmentation and clinical readouts on recorded procedures15 结构分割与临床读数,在录像病例上运行
  • Held-out benchmark: 34 patients, two centres, no overlap with training留出验证:34 位患者、两个中心、与训练零重叠
  • Outcome-linked cohort of 203 intra-procedural studies203 例术中检查的结局关联队列
Not yet尚未
  • Use during patient care用于患者诊疗
  • External validation外部验证
  • Regulatory clearance of any kind任何监管许可
05Why now为什么是现在

The third generation of edge-to-edge repair.缘对缘修复的第三代。

1991 · Surgical外科

The Alfieri stitchAlfieri 缝合

One suture between the free edges of the two leaflets, Milan. A simple, reproducible repair.米兰。一针缝合两侧瓣叶的游离缘,简单、可重复的修复。

2003 · Transcatheter经导管

The clip, first-in-human夹子首次用于人体

The same repair delivered through a catheter and judged on echo. 300,000+ patients; guideline therapy.同样的修复经导管完成,在超声上判断。30 万+ 患者,写入指南。

2026 · AI-guidedAI 引导

AutoClip

The machine learns to see the repair on the echo image. Every decision made by eye gets a number.机器学会在超声图像上看懂这台修复。每个靠肉眼的决策都有了数字。

06Team团队

An operator and a computer-vision scientist.一位术者,一位计算机视觉科学家。

Portrait of Mi Chen
Founder & CEO创始人 · CEO

Mi Chen, MD PhD 陈密

  • Cardiac surgeon and TEER / TAVI operator; 1,700+ structural heart procedures as operator and team member心脏外科医生,TEER / TAVI 术者;主刀与参与结构性心脏手术 1,700+ 例
  • Trained at Fuwai Hospital, Beijing; structural heart fellowship at University Hospital Zürich and Klinik Hirslanden北京阜外医院训练;苏黎世大学医院与 Hirslanden 医院结构性心脏病 fellowship
  • Faculty at TCT, EuroPCR and PCR London ValvesTCT、EuroPCR、PCR London Valves 讲者
  • Writes the model code herself模型代码由她本人编写
Portrait of Denis Samuylov
Co-founder & CTO联合创始人 · CTO

Denis Samuylov, PhD

  • PhD in computer vision, ETH Zürich; a decade in the field苏黎世联邦理工学院计算机视觉博士,深耕十年
  • Co-founder of GenAI Zürich, the applied-AI event series应用 AI 系列活动 GenAI Zürich 联合创始人
  • Owns the architecture and the real-time inference pipeline负责系统架构与实时推理管线
Mi Chen at the table during a live-transmitted structural heart case in Zürich, fluoroscopy screens behind her, broadcast cameras in the foreground
Live teaching case · Zürich · 2024教学直播病例 · 苏黎世 · 2024
“AutoClip is the tool I wanted on the screen every time I clipped a valve.”「AutoClip 是我每次夹瓣膜时,都希望屏幕上有的那个工具。」 Mi Chen
07Where this goes方向

The intelligence layer of cardiac medicine.心脏医学的智能层。

We start with the mitral clip. The goal is AI that understands the beating heart in real time, for every catheter procedure. The operating room comes first because it is where perception and action already meet, and every case closes the loop.我们从二尖瓣夹子开始。目标是能实时理解跳动心脏的 AI,服务每一台导管手术。先从手术室做起,因为那里感知与动作已经相遇,每一台手术都让闭环转一圈。

  • Now现在Mitral TEER二尖瓣 TEER · one workflow, validated at outside centres一个工作流,在外部中心验证
  • Next下一步Tricuspid TEER, TAVI三尖瓣 TEER、TAVI · one shared heart model across procedures跨术式共用一个心脏模型
  • Later之后Beyond the valve瓣膜之外 · only where the evidence carries over只在证据能迁移的地方
TWO FLYWHEELSONE PATIENT MODEL Understand理解 ANATOMY & FUNCTION解剖与功能 Predict预测 WHO BENEFITS, WHEN谁获益、何时 Plan规划 DEVICE, STRATEGY器械与策略 Guide引导 NOW · AUTOCLIP现在 · AUTOCLIP Learn学习 OUTCOMES AT 1 YEAR一年结局